Disease Response Simulator
by Generative Geometry
Guide
Drug reference
generativegeometry.science
Research tool — not medical advice.
Structural predictions from a mathematical formula. Not clinically validated. Must not guide treatment decisions.
Clear all
Existing treatments
Select agents or load a treatment
What matters
Patient immune profile
Enter immune markers to classify this patient's Observer state and personalise the prediction.
Immune markers
PD-L1 proxy
Manual
CD8+ T-cell fraction
Treg fraction (of T-cells)
From tumour microenvironment analysis (e.g. CIBERSORT, single-cell RNA-seq). CD8 median: 0.11, Treg fraction median: 0.12 (TCGA pan-cancer).
PD-L1 TPS (%)
PD-L1 is a proxy, not a direct measurement. TPS ≥50%: likely Withdraw (immune suppressed but intact). TPS 1–49%: likely Drain. TPS <1%: likely Confusion. This mapping is approximate.
Attend
High CD8, Low Treg
Drain
High CD8, High Treg
Withdraw
Low CD8, Low Treg
Confusion
Low CD8, High Treg
Clear patient state
Patient scenarios
Combination model
To improve coverage
▸ Treatment timeline
Week
0
▸ How the score is built
H
=hold
×
=cross ·
L1
=surface
L2
=pathway
L3
=structural
L4
=genomic
Generative Geometry (van der Klein, 2026) · DRS v5
Predicting…