Classification of every agent in the Drug Response Simulator — drug class, target pathway, mechanism, potency, and calibration source.
Calibrated against trial Estimated from mechanism
How to read this page. Each drug has a drug class (mechanism category), a target pathway (which part of the tumour cycle it disrupts), a mechanism (how it works), and a potency M (how effectively it blocks). Some agents appear in multiple cancer types with different M values — the same drug may be more or less effective depending on the tumour biology.
Confidence scores reflect how the M value was determined:
90+Single-agent pivotal trial. M back-calculated directly from a randomised or large single-agent study against this cancer type. Highest confidence.
80+Combination trial control arm. The drug appeared in a combination study but the control arm isolates its single-agent contribution. High confidence.
55Historical data. M derived from older or less controlled data. Moderate confidence.
45Class extrapolation. No own trial data. M estimated from a similar drug in the same class (e.g. Anastrozole from Letrozole). Low-moderate confidence.
30Mechanism estimate. No trial data for this drug or class in this cancer type. M estimated from mechanism of action alone. Lowest confidence — these are the parameters most in need of clinical validation.